Who Was America's Deadliest Serial Killer?
Samuel Little, who was active between 1970 and 2005, holds the grim title of the most prolific serial killer in U.S. history, according to the FBI. His staggering confession of 93 murders has been linked to 60 confirmed cases, although law enforcement continues to verify more of his claims. Little's victims were primarily women from marginalized backgrounds, often sex workers or individuals struggling with addiction. These women were easy targets for a man who knew how to exploit their vulnerability.
The Crimes
Samuel Little. Photo courtesy of the LAPD. Public domain.
Samuel Little targeted victims across the country, from Florida to California, living a nomadic lifestyle that allowed him to kill without drawing suspicion. His method was consistent and brutal — he would typically strangle his victims, a detail that often led medical examiners to rule the deaths as accidental overdoses or natural causes. For decades, his crimes went undetected because many of his victims' deaths were not initially classified as homicides.
In 2012, Little was finally arrested on drug charges in Kentucky. When authorities took a DNA sample, it matched him to three cold cases in California. This led to his life imprisonment. While incarcerated, he began confessing to dozens more murders, offering detailed descriptions that helped investigators match his confessions to unsolved cases across the U.S.
The Investigation Breakthrough
Years of mugshots taken of serial killer Samuel Little from 1966 to 1995. Photo courtesy of the FBI. Public domain.
One of the key elements that set Little apart from other serial killers was the sheer number of his victims and his ability to evade capture for so long. His victims, many of whom were poor women of color, were often disregarded by the system. Because their deaths were not always investigated thoroughly, Little was able to continue killing undetected for decades. It wasn't until advancements in DNA technology that his crimes began to unravel.
When Little began confessing, his ability to recall precise details shocked investigators. He could remember not only the women he killed, but also where he left their bodies. He even provided investigators with hand-drawn sketches of his victims, which have helped identify some of the women who were previously considered "Jane Does."
Legacy and Ongoing Investigations
Little's death in 2020 at age 80 did not bring closure to all of his cases. The FBI is still working with local law enforcement across the country to verify the remaining confessions. His case has highlighted the systemic failures in investigating murders involving marginalized women, and it has prompted a reexamination of how law enforcement handles cases involving vulnerable populations.
Samuel Little's reign of terror serves as a haunting reminder of how killers can hide in plain sight for decades, especially when their victims are overlooked by society. His confessions have forever changed the landscape of serial killer investigations in the U.S.
References: The Grisly Story Of Samuel Little, The Most Prolific Serial Killer In American History | Samuel Little: Most prolific serial killer in US history dies in California hospital | FBI Confirms Samuel Little is Most Prolific Serial Killer in U.S. History
